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Quick Biochemistry - Enzymes (Section 1 - No. 17)

According to the 'lock and key' model of enzyme action, what is the relationship between the enzyme's active site and the substrate?
The active site is complementary in shape to that of substance only after interaction.
The active site is complementary in shape to that of substance
Substrates change conformation prior to active site interaction
The active site is flexible and adjusts to substrate

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